Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.66 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | CD38 | P28907 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182495 | 0.83 | PIK3CA (0.58) | MAP4K4PIK3CDPIK3CAPIK3CBKCNH2 | |
| SCHEMBL182914 | 0.82 | MKNK1 (0.64) | MKNK1MKNK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL183106 | 0.82 | PIK3CD (0.65) | MAP4K4CYP11B1CYP11B2PIK3CDPIK3CA | |
| SCHEMBL183174 | 0.82 | PIK3CA (0.57) | MAP4K4PIK3CDPIK3CAPIK3CBKCNH2 | |
| SCHEMBL182536 | 0.80 | PIK3CA (0.60) | MAP4K4PIK3CDPIK3CAPIK3CBKCNH2 | |
| SCHEMBL17665897 | 0.78 | MAP4K4 (0.72) | MAP4K4CYP11B1CYP11B2IRAK4CYP1A2 | |
| SCHEMBL182628 | 0.77 | MAPK1 (0.57) | PIK3CDPIK3CAPIK3CBKCNH2CHEK2 | |
| SCHEMBL183097 | 0.77 | MKNK1 (0.61) | MKNK1MKNK2MAP4K4PIK3CDPIK3CA | |
| SCHEMBL5569427 | 0.77 | KIT (0.58) | MKNK1MKNK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL183031 | 0.76 | MAPK1 (0.48) | MKNK1MKNK2MAP4K4PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | claimed |
| US-20090258882-A1 | 2,4-Substituted Quinazolines as Lipid Kinase Inhibitors | NOVARTIS AG | 2009-10-15 | — | — | US | claimed |
| EP-2049502-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | Novartis AG (CH) | 2009-04-22 | — | — | EP | claimed |
| WO-2008012326-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-31 | — | — | WO | claimed |
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258882-A1 | 2,4-Substituted Quinazolines as Lipid Kinase Inhibitors | PDPK1, PI4KA, PIK3CA | MKNK1 153/4885MKNK2 136/4885MAP4K4 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.