Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 4/20 | 0.60 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.59 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.58 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.55 |
| ▸ | ERN1 | O75460 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182950 | 0.88 | MAP4K1 (0.60) | GAKMAP4K1TLR8TLR7PIK3CD | |
| SCHEMBL182816 | 0.85 | MAP4K1 (0.61) | MAP4K1TLR8TLR7PIK3CDPIK3CA | |
| SCHEMBL182675 | 0.84 | PIK3CD (0.52) | GAKMAP4K1TLR8TLR7PIK3CD | |
| SCHEMBL182858 | 0.84 | PIK3CD (0.67) | GAKMAP4K1TLR8TLR7PIK3CD | |
| SCHEMBL28776662 | 0.82 | TLR8 (0.50) | GAKMAP4K1TLR8TLR7PIK3CD | |
| SCHEMBL28776661 | 0.82 | PIK3CD (0.51) | MAP4K1TLR8TLR7PIK3CDPIK3CA | |
| SCHEMBL4355316 | 0.82 | GAK (0.83) | GAKPDE10AMEN1ALDH1A1LMNA | |
| SCHEMBL182904 | 0.81 | PIK3CD (0.57) | TLR8TLR7PIK3CDPIK3CAPIK3CB | |
| SCHEMBL27767855 | 0.81 | PIK3CD (0.49) | MAP4K1TLR8TLR7PIK3CDPIK3CA | |
| SCHEMBL324652 | 0.80 | PIK3CD (0.49) | MAP4K1TLR8TLR7PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | claimed |
| US-20090258882-A1 | 2,4-Substituted Quinazolines as Lipid Kinase Inhibitors | NOVARTIS AG | 2009-10-15 | — | — | US | claimed |
| EP-2049502-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | Novartis AG (CH) | 2009-04-22 | — | — | EP | claimed |
| WO-2008012326-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-31 | — | — | WO | claimed |
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258882-A1 | 2,4-Substituted Quinazolines as Lipid Kinase Inhibitors | PDPK1, PI4KA, PIK3CA | GAK 77/4885MAP4K1 47/4885TLR8 1188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.