Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18258690 | 1.00 | PDE4B (0.63) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL3203527 | 0.94 | PDE4B (0.64) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL3203533 | 0.94 | PDE4B (0.64) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL3213130 | 0.93 | PDE4B (0.63) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL3213125 | 0.93 | PDE4B (0.63) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL3211094 | 0.93 | PDE4B (0.63) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL3211091 | 0.93 | PDE4B (0.63) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL3204902 | 0.90 | PDE4B (0.60) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL3204905 | 0.90 | PDE4B (0.60) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL7961701 | 0.90 | PDE4B (0.60) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2778156-B1 | Phenoxypyridinylamide derivatives and their use in the treatment of PDE4 mediated disease states | ASTRAZENECA AB (SE) | 2016-11-30 | — | — | EP | disclosed |