SCHEMBL18258917

SCHEMBL18258917

Cc1cnc(Oc2ccc3nc(COc4cccc(C(=O)C(O)c5ccccc5)c4)n(C)c3c2)c(F)c1

nearest known ligand 0.80

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18258916 0.95 PPARG (0.77) PPARG
SCHEMBL502825 0.89 PPARG (1.00) PPARG
SCHEMBL502836 0.86 PPARG (0.84) PPARG
SCHEMBL502814 0.81 PPARG (1.00) PPARG
SCHEMBL502611 0.80 PPARG (1.00) PPARG
SCHEMBL502892 0.80 PPARG (0.85) PPARG
SCHEMBL29574037 0.78 PPARG (0.84) PPARG
SCHEMBL502569 0.78 PPARG (0.84) PPARG
SCHEMBL503095 0.78 PPARG (1.00) PPARG
SCHEMBL503085 0.77 PPARG (0.85) PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2404918-B1 PYRIDINE DERIVATIVE AS PPARY INHIBITOR DAIICHI SANKYO CO LTD (JP) 2016-11-30 EP claimed