Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1612854 | 0.84 | SRC (0.43) | LRRK2ALKINSRATRSRC | |
| SCHEMBL1822070 | 0.81 | LRRK2 (0.48) | LRRK2ALKINSR | |
| SCHEMBL12713954 | 0.78 | ERBB2 (0.40) | ALKINSRATRSRCCHEK1 | |
| SCHEMBL1613257 | 0.78 | ERBB2 (0.40) | ALKINSRATRSRCCHEK1 | |
| SCHEMBL1613407 | 0.78 | ERBB2 (0.40) | ALKINSRATRSRCCHEK1 | |
| SCHEMBL1612972 | 0.78 | SRC (0.45) | ATRSRCCHEK1 | |
| SCHEMBL1612980 | 0.70 | PIK3CA (0.35) | LRRK2TBK1ATRSRCCHEK1 | |
| SCHEMBL1612455 | 0.70 | ALOX5AP (0.38) | TBK1ATR | |
| SCHEMBL1613268 | 0.69 | SYK (0.44) | TBK1 | |
| SCHEMBL1614063 | 0.67 | LRRK2 (0.40) | LRRK2ATRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315751-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | Amgen Inc. (US) | 2011-05-04 | — | — | EP | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |