Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 10/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 2/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18263126 | 0.81 | FYN (0.58) | MAP4K4EGLN1FYNATRUSP7 | |
| SCHEMBL18240070 | 0.81 | FYN (0.58) | MAP4K4EGLN1FYNUSP7 | |
| SCHEMBL488494 | 0.80 | USP7 (0.62) | MAP4K4EGLN1FYNRAB9AADORA1 | |
| SCHEMBL14157215 | 0.80 | FYN (0.59) | MAP4K4EGLN1FYNUSP7 | |
| SCHEMBL18263116 | 0.80 | FYN (0.69) | MAP4K4FYNBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL18616318 | 0.78 | PIK3CB (0.66) | MAP4K4FYNATR | |
| SCHEMBL15344198 | 0.77 | EGLN1 (0.47) | MAP4K4EGLN1RAB9AADORA1NPC1 | |
| SCHEMBL13040 | 0.77 | MAP4K4 (0.66) | MAP4K4RAB9AADORA1NPC1 | |
| SCHEMBL20171251 | 0.76 | EGLN1 (0.51) | EGLN1 | |
| SCHEMBL18263158 | 0.76 | EGLN1 (0.54) | MAP4K4EGLN1ADORA1ATRUSP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145935-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | Universiteit Leiden (NL) | 2017-03-29 | — | — | EP | disclosed |
| WO-2016188972-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | UNIVERSITEIT LEIDEN (NL) | 2016-12-01 | — | — | WO | disclosed |
| WO-2016188972-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | UNIVERSITEIT LEIDEN (NL) | 2016-12-01 | — | — | WO | disclosed |