Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 10/20 | 0.58 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | JUN | P05412 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15344630 | 0.74 | MAPK9 (1.00) | MAPK9IRAK4MAPK10MAPK8FLT3 | |
| SCHEMBL7887171 | 0.74 | MAPK9 (1.00) | MAPK9IRAK4MAPK10MAPK8FLT3 | |
| SCHEMBL7887172 | 0.73 | MAPK9 (1.00) | MAPK9IRAK4MAPK10MAPK8FLT3 | |
| SCHEMBL15344589 | 0.73 | MAPK9 (1.00) | MAPK9IRAK4MAPK10MAPK8FLT3 | |
| SCHEMBL7884537 | 0.72 | MAPK9 (1.00) | MAPK9IRAK4MAPK10MAPK8FLT3 | |
| SCHEMBL183868 | 0.71 | MAPK9 (0.54) | MAPK9DYRK1AFLT3CDK2 | |
| SCHEMBL183139 | 0.69 | MAPK9 (0.79) | MAPK9IRAK4MAPK10MAPK8FLT3 | |
| SCHEMBL21067899 | 0.66 | IRAK4 (1.00) | MAPK9IRAK4MAPK10DYRK1AMAPK8 | |
| SCHEMBL7884533 | 0.66 | MAPK9 (1.00) | MAPK9IRAK4MAPK10MAPK8FLT3 | |
| SCHEMBL182609 | 0.66 | MAPK9 (0.72) | MAPK9IRAK4MAPK10MAPK8FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401274-B1 | IMIDAZO[1,2-A]PYRIDINES AS JNK MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-10-22 | — | — | EP | claimed |
| US-8569306-B2 | JNK modulators | HOFFMANN-LA ROCHE, INC. (US) | 2013-10-29 | — | — | US | claimed |
| EP-2401274-A1 | IMIDAZO [1, 2 -A]PYRIDINES AS JNK MODULATORS | F. Hoffmann-La Roche AG (CH) | 2012-01-04 | — | — | EP | claimed |
| US-20110306618-A1 | JNK Modulators | BUETTELMANN BERND (DE) | 2011-12-15 | — | — | US | claimed |
| WO-2010097335-A1 | IMIDAZO [1, 2 -A] PYRIDINES AS JNK MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-02 | — | — | WO | claimed |
| EP-2401274-B1 | IMIDAZO[1,2-A]PYRIDINES AS JNK MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-10-22 | — | — | EP | disclosed |
| US-8569306-B2 | JNK modulators | HOFFMANN-LA ROCHE, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| EP-2401274-A1 | IMIDAZO [1, 2 -A]PYRIDINES AS JNK MODULATORS | F. Hoffmann-La Roche AG (CH) | 2012-01-04 | — | — | EP | disclosed |
| US-20110306618-A1 | JNK Modulators | BUETTELMANN BERND (DE) | 2011-12-15 | — | — | US | disclosed |
| WO-2010097335-A1 | IMIDAZO [1, 2 -A] PYRIDINES AS JNK MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306618-A1 | JNK Modulators | MAPK3, MAPK1, MAPK4 | MAPK9 15/4885IRAK4 1050/4885MAPK10 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.