⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28363554 | 1.00 | — | — | |
| SCHEMBL12641503 | 1.00 | — | — | |
| SCHEMBL5988542 | 0.90 | CYP1A2 (0.62) | — | |
| SCHEMBL5105796 | 0.90 | CYP1A2 (0.62) | — | |
| SCHEMBL28237732 | 0.88 | CYP1A2 (0.71) | — | |
| SCHEMBL8710704 | 0.88 | CYP1A2 (0.71) | — | |
| SCHEMBL28238797 | 0.88 | CYP1A2 (0.71) | — | |
| SCHEMBL664978 | 0.86 | CYP1A2 (0.69) | — | |
| SCHEMBL6662416 | 0.86 | CYP1A2 (0.69) | — | |
| SCHEMBL28296028 | 0.86 | CYP1A2 (0.69) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 215 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119876055-A | Alkene reductase mutant and application thereof in preparation of buvaracetam intermediate | 华东理工大学 | 2025-04-25 | — | — | CN | claimed |
| CN-119432782-A | Alkene reductase mutant and application thereof in catalytic preparation of buvaracetam synthesis intermediate | 上海医药工业研究院有限公司 | 2025-02-14 | — | — | CN | claimed |
| CN-119265149-A | Ketene reductase and method for preparing buvaracetam intermediate by using same | 弈柯莱生物科技(集团)股份有限公司 | 2025-01-07 | — | — | CN | claimed |
| CN-115466233-B | Synthesis method of buvaracetam intermediate (R) -4-propyl-dihydrofuran-2-one | 合肥立方制药股份有限公司 | 2024-08-23 | — | — | CN | claimed |
| CN-117701649-B | Synthesis method of buvaracetam key intermediate | 山东静远药业有限公司 | 2024-06-14 | — | — | CN | claimed |
| CN-116948997-B | Olefin reductase mutant and application thereof in preparation of (R) -4-propyldihydrofuran-2 (3H) -ketone | 江南大学 | 2024-05-24 | — | — | CN | claimed |
| CN-117964584-A | Synthesis method of (R) -4-propyl-dihydrofuran-2-one | 江苏同禾药业有限公司 | 2024-05-03 | — | — | CN | claimed |
| CN-114751849-B | Preparation method of brivaracetam and intermediate compound | 四川奥邦古得药业有限公司 | 2024-03-22 | — | — | CN | claimed |
| CN-117701649-A | Synthesis method of buvaracetam key intermediate | 山东静远药业有限公司 | 2024-03-15 | — | — | CN | claimed |
| CN-117658956-A | Preparation method of chiral (R) -4-n-propyl-dihydrofuran-2 (3H) -ketone | 新天地医药技术研究院(郑州)有限公司 | 2024-03-08 | — | — | CN | claimed |
| CN-112521352-A | Preparation method of brivaracetam intermediate | 北京万全德众医药生物技术有限公司 | 2021-03-19 | — | — | CN | claimed |
| CN-112521351-A | Preparation method of brivaracetam intermediate | 北京万全德众医药生物技术有限公司 | 2021-03-19 | — | — | CN | claimed |
| CN-109266630-B | Lipase and application thereof in preparation of brivaracetam intermediate | 弈柯莱生物科技(上海)股份有限公司 | 2021-02-02 | — | — | CN | claimed |
| CN-112062740-A | Synthesis method of (R) -4-propyl dihydrofuran-2-ketone | 深圳市华先医药科技有限公司 | 2020-12-11 | — | — | CN | claimed |
| CN-111693634-A | Gas chromatography detection method of related substances of brivaracetam intermediate | 万全万特制药（厦门）有限公司 | 2020-09-22 | — | — | CN | claimed |
| CN-111349007-A | Preparation method of (R) -4-propyl-dihydrofuran-2-ketone and preparation intermediate thereof | 浙江京新药业股份有限公司 | 2020-06-30 | — | — | CN | claimed |
| CN-108530402-B | Preparation method of (R) -3-propyl-gamma-butyrolactone | 浙江工业大学 | 2020-06-26 | — | — | CN | claimed |
| CN-108203419-B | Preparation method of brivaracetam intermediate | 浙江京新药业股份有限公司 | 2020-04-28 | — | — | CN | claimed |
| CN-108503609-B | Method for preparing optically pure (R) -4-n-propyl-dihydrofuran-2 (3H) -ketone | 北京艾百诺医药股份有限公司 | 2019-12-24 | — | — | CN | claimed |
| EP-3543229-A1 | METHOD FOR PREPARING OPTICALLY PURE (R)-4-N-PROPYL-DIHYDROFURAN-2(3H)-ONE | Beijing AblePharmtech Co., Ltd. (CN) | 2019-09-25 | — | — | EP | claimed |