Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.46 |
| ▸ | POLA1 | P09884 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.34 |
| ▸ | ALB | P02768 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.34 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.34 |
| ▸ | POLG | P54098 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | ST6GAL1 | P15907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18263819 | 1.00 | PDE3A (0.46) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL20213094 | 1.00 | PDE3A (0.46) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL20221826 | 0.90 | PDE3A (0.43) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL20221801 | 0.90 | PDE3A (0.43) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL31614572 | 0.88 | PDE3A (0.43) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL20213197 | 0.86 | PDE3A (0.44) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL20213195 | 0.86 | PDE3A (0.44) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL10062707 | 0.83 | PDE3A (0.38) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL30404766 | 0.82 | PDE3A (0.42) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL17099312 | 0.82 | PDE3A (0.40) | PDE3APDE4DSLC29A1POLA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303359-A1 | NUCLEOTIDES FOR THE TREATMENT OF CANCER | Idenix Pharmaceuticals LLC (US) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016188943-A1 | NUCLEOTIDES FOR THE TREATMENT OF CANCER | IDENIX PHARMACEUTICALS LLC (US) | 2016-12-01 | — | — | WO | disclosed |