Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.36 |
| ▸ | GSK3B | P49841 | 7/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.36 |
| ▸ | SRC | P12931 | 5/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18264156 | 0.80 | NPY5R (0.50) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL21840862 | 0.80 | SLC2A1 (0.55) | KDRSLC2A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18264402 | 0.78 | EGFR (0.47) | AURKAGSK3BAURKBMAP4K4CSF1R | |
| SCHEMBL18264175 | 0.76 | KDM1A (0.52) | GSK3BAURKBMAP4K4CSF1RFGFR1 | |
| SCHEMBL18264159 | 0.73 | MAPT (0.52) | KDRMEN1NPC1RAB9AKMT2A | |
| SCHEMBL18264161 | 0.73 | ABCG2 (0.51) | KDRCLK4MEN1NPC1RAB9A | |
| SCHEMBL18264174 | 0.73 | GAA (0.52) | MEN1KMT2ANTRK1 | |
| SCHEMBL18264404 | 0.73 | KMT2A (0.48) | AURKBMAP4K4CSF1RFGFR1PDGFRA | |
| SCHEMBL18264139 | 0.73 | KDM1A (0.52) | AURKAGSK3BAURKBSRCMAP4K4 | |
| SCHEMBL18264134 | 0.73 | NPY5R (0.53) | SLC2A1MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3302060-B1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF -GLUCURONIDASE | UNIV KAOHSIUNG MEDICAL (TW) | 2020-02-12 | — | — | EP | claimed |
| US-20180214426-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF BETA-GLUCURONIDASE | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2018-08-02 | — | — | US | claimed |
| EP-3302060-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF -GLUCURONIDASE | Kaohsiung Medical University (TW) | 2018-04-11 | — | — | EP | claimed |
| WO-2016191576-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF β-GLUCURONIDASE | DCB-USA LLC (US) | 2016-12-01 | — | — | WO | claimed |
| EP-3662751-B1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF B-GLUCURONIDASE | UNIV KAOHSIUNG MEDICAL (TW) | 2021-10-13 | — | — | EP | disclosed |
| US-11135206-B2 | Pyrazolo[4,3-c]quinoline derivatives for inhibition of β-glucuronidase | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2021-10-05 | — | — | US | disclosed |
| US-11052072-B2 | Pyrazolo[4,3-C] quinoline derivatives for inhibition of β-glucuronidase | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2021-07-06 | — | — | US | disclosed |
| EP-3662751-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF B-GLUCURONIDASE | Kaohsiung Medical University (TW) | 2020-06-10 | — | — | EP | disclosed |
| US-20200113878-A1 | PYRAZOLO[4,3-C]Quinoline Derivatives For Inhibition Of Beta-Glucuronidase | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2020-04-16 | — | — | US | disclosed |
| EP-3302060-B1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF -GLUCURONIDASE | UNIV KAOHSIUNG MEDICAL (TW) | 2020-02-12 | — | — | EP | disclosed |
| US-20180214426-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF BETA-GLUCURONIDASE | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2018-08-02 | — | — | US | disclosed |
| EP-3302060-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF -GLUCURONIDASE | Kaohsiung Medical University (TW) | 2018-04-11 | — | — | EP | disclosed |
| CN-107708419-A | Pyrazolo [4,3-c ] quinoline derivatives having inhibitory activity on bacterial glucuronidase | 高雄医学大学 | 2018-02-16 | — | — | CN | disclosed |
| WO-2016191576-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF β-GLUCURONIDASE | DCB-USA LLC (US) | 2016-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180214426-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF BETA-GLUCURONIDASE | UGT1A3, UGT1A1, GUSB | AURKA 1626/4885GSK3B 2314/4885AURKB 2276/4885 |
| US-20200113878-A1 | PYRAZOLO[4,3-C]Quinoline Derivatives For Inhibition Of Beta-Glucuronidase | UGT1A3, UGT1A1, GUSB | AURKA 1626/4885GSK3B 2314/4885AURKB 2276/4885 |
| US-11052072-B2 | Pyrazolo[4,3-C] quinoline derivatives for inhibition of β-glucuronidase | UGT1A3, UGT1A1, DPP3 | AURKA 1628/4885GSK3B 2386/4885AURKB 2273/4885 |
| US-11135206-B2 | Pyrazolo[4,3-c]quinoline derivatives for inhibition of β-glucuronidase | UGT1A3, UGT1A1, DPP3 | AURKA 1628/4885GSK3B 2386/4885AURKB 2273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.