Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.63 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.63 |
| ▸ | MTOR | P42345 | 6/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 3/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | HCK | P08631 | 5/20 | 0.46 |
| ▸ | SRC | P12931 | 5/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.46 |
| ▸ | PRKDC | P78527 | 5/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182747 | 1.00 | PIK3CD (0.63) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL182951 | 0.99 | PIK3CD (0.64) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL182537 | 0.99 | PIK3CD (0.64) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL182852 | 0.99 | PIK3CD (0.64) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL182771 | 0.91 | PIK3CD (0.73) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL4502927 | 0.88 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL183173 | 0.87 | PIK3CD (0.63) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL182628 | 0.86 | MAPK1 (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL182889 | 0.86 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL182667 | 0.86 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | claimed |
| CN-101490016-A | 2,4-substituted quinazolines as lipid kinase inhibitors | NOVARTIS AG (CH) | 2009-07-22 | — | — | CN | claimed |
| EP-2049502-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | Novartis AG (CH) | 2009-04-22 | — | — | EP | claimed |
| WO-2008012326-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-31 | — | — | WO | claimed |
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | disclosed |
| CN-101490016-A | 2,4-substituted quinazolines as lipid kinase inhibitors | NOVARTIS AG (CH) | 2009-07-22 | — | — | CN | disclosed |