Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 19/20 | 0.76 |
| ▸ | FGFR1 | P11362 | 17/20 | 0.76 |
| ▸ | FGFR3 | P22607 | 16/20 | 0.76 |
| ▸ | ABL1 | P00519 | 3/20 | 0.57 |
| ▸ | EGFR | P00533 | 3/20 | 0.57 |
| ▸ | INSR | P06213 | 3/20 | 0.57 |
| ▸ | RET | P07949 | 3/20 | 0.57 |
| ▸ | SRC | P12931 | 3/20 | 0.57 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.57 |
| ▸ | LTK | P29376 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | MERTK | Q12866 | 3/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.57 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.57 |
| ▸ | ROS1 | P08922 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28371016 | 0.90 | FGFR2 (0.75) | FGFR2FGFR1FGFR3ABL1EGFR | |
| SCHEMBL18271260 | 0.90 | FGFR2 (0.74) | FGFR2FGFR1FGFR3ABL1EGFR | |
| SCHEMBL18271366 | 0.90 | FGFR2 (0.62) | FGFR2FGFR1FGFR3ABL1EGFR | |
| SCHEMBL18271233 | 0.90 | FGFR2 (0.76) | FGFR2FGFR1FGFR3ABL1EGFR | |
| SCHEMBL28371018 | 0.89 | FGFR2 (0.63) | FGFR2FGFR1FGFR3ABL1EGFR | |
| SCHEMBL18271388 | 0.88 | FGFR2 (0.61) | FGFR2FGFR1FGFR3ABL1EGFR | |
| SCHEMBL18271322 | 0.88 | FGFR2 (0.65) | FGFR2FGFR1FGFR3ABL1EGFR | |
| SCHEMBL28886192 | 0.88 | FGFR2 (0.68) | FGFR2FGFR1FGFR3ABL1EGFR | |
| SCHEMBL18271235 | 0.87 | FGFR2 (0.61) | FGFR2FGFR1FGFR3ABL1EGFR | |
| SCHEMBL18271321 | 0.87 | FGFR2 (0.66) | FGFR2FGFR1FGFR3ABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106279101-B | Benzopyrazolopyridines, pharmaceutical compositions comprising same and use thereof | 中国科学院上海药物研究所 | 2020-03-17 | — | — | CN | disclosed |
| WO-2016188481-A1 | PYRAZOLOPHENYL-PYRIDINE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF | 中国科学院上海药物研究所 | 2016-12-01 | — | — | WO | disclosed |