Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.53 |
| ▸ | LCK | P06239 | 12/20 | 0.53 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | BTK | Q06187 | 9/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20539873 | 0.97 | JAK3 (0.56) | JAK3LCKEGFRBTK | |
| SCHEMBL18283986 | 0.97 | JAK3 (0.56) | JAK3LCKEGFRBTK | |
| SCHEMBL18283741 | 0.97 | JAK3 (0.56) | JAK3LCKEGFRBTK | |
| SCHEMBL18284141 | 0.97 | JAK3 (0.56) | JAK3LCKEGFRBTK | |
| SCHEMBL18283703 | 0.97 | JAK3 (0.56) | JAK3LCKEGFRBTK | |
| SCHEMBL23080646 | 0.88 | JAK3 (0.54) | JAK3LCKEGFRBTK | |
| SCHEMBL18284073 | 0.87 | JAK3 (0.52) | JAK3LCKEGFRBTK | |
| SCHEMBL23080649 | 0.84 | BTK (0.48) | JAK3LCKEGFRBTK | |
| SCHEMBL20540845 | 0.83 | JAK3 (0.75) | JAK3LCKEGFRBTK | |
| SCHEMBL18284033 | 0.83 | JAK3 (0.75) | JAK3LCKEGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | Pharmacyclics LLC (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |