Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 13/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.59 |
| ▸ | LMNA | P02545 | 8/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.56 |
| ▸ | USP2 | O75604 | 9/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.56 |
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL183208 | 0.87 | PIK3CD (0.58) | CLK4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL182495 | 0.87 | PIK3CA (0.58) | CLK4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL183174 | 0.86 | PIK3CA (0.57) | CLK4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL183018 | 0.86 | PIK3CD (0.57) | CLK4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL182885 | 0.84 | PIK3CD (0.56) | CLK4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL182889 | 0.84 | PIK3CD (0.67) | CLK4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL182536 | 0.84 | PIK3CA (0.60) | CLK4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL182771 | 0.83 | PIK3CD (0.73) | CLK4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL182628 | 0.81 | MAPK1 (0.57) | CLK4HSD17B10ALDH1A1MAPK1TSHR | |
| SCHEMBL182955 | 0.81 | PIK3CD (0.61) | CLK4PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | claimed |
| US-20090258882-A1 | 2,4-Substituted Quinazolines as Lipid Kinase Inhibitors | NOVARTIS AG | 2009-10-15 | — | — | US | claimed |
| EP-2049502-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | Novartis AG (CH) | 2009-04-22 | — | — | EP | claimed |
| WO-2008012326-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-31 | — | — | WO | claimed |
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258882-A1 | 2,4-Substituted Quinazolines as Lipid Kinase Inhibitors | PDPK1, PI4KA, PIK3CA | CLK4 586/4885CYP3A4 1218/4885CYP1A2 622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.