Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.83 |
| ▸ | CCNE1 | P24864 | 14/20 | 0.83 |
| ▸ | CDK1 | P06493 | 13/20 | 0.83 |
| ▸ | CCNB1 | P14635 | 13/20 | 0.83 |
| ▸ | CDK6 | Q00534 | 7/20 | 0.83 |
| ▸ | CCND3 | P30281 | 2/20 | 0.83 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.83 |
| ▸ | CDK9 | P50750 | 1/20 | 0.83 |
| ▸ | CDK2 | P24941 | 6/20 | 0.68 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18288853 | 0.94 | CDK4 (0.81) | CDK4CCNE1CDK1CCNB1CDK6 | |
| SCHEMBL18288928 | 0.93 | CDK4 (0.73) | CDK4CCNE1CDK1CCNB1CDK6 | |
| SCHEMBL18288910 | 0.93 | CDK4 (0.83) | CDK4CCNE1CDK1CCNB1CDK6 | |
| SCHEMBL18288767 | 0.93 | CDK4 (0.73) | CDK4CCNE1CDK1CCNB1CDK6 | |
| SCHEMBL18288962 | 0.93 | CDK4 (0.73) | CDK4CCNE1CDK1CCNB1CDK6 | |
| SCHEMBL18288940 | 0.93 | CDK4 (0.82) | CDK4CCNE1CDK1CCNB1CDK6 | |
| SCHEMBL18288931 | 0.92 | CDK4 (0.84) | CDK4CCNE1CDK1CCNB1CDK6 | |
| SCHEMBL18289042 | 0.92 | CDK4 (0.84) | CDK4CCNE1CDK1CCNB1CDK6 | |
| SCHEMBL18288395 | 0.91 | CDK4 (0.74) | CDK4CCNE1CDK1CCNB1CDK6 | |
| SCHEMBL18288802 | 0.91 | CDK4 (1.00) | CDK4CCNE1CDK1CCNB1CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016192630-A1 | COMPOUND HAVING KINASE INHIBITING ACTIVITY, METHOD OF PREPARING SAME, AND USE OF SAME | 中国科学院上海药物研究所 | 2016-12-08 | — | — | WO | disclosed |