Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22544270 | 0.84 | RAD52 (0.49) | PNMTRAD52RECQLMAPTTP53 | |
| SCHEMBL18288835 | 0.81 | CDK1 (0.41) | MAPTTP53KMT2AMEN1NPC1 | |
| SCHEMBL1038680 | 0.80 | KMT2A (0.63) | PNMTMAPTTP53KMT2AMEN1 | |
| SCHEMBL29883119 | 0.80 | KMT2A (0.63) | PNMTMAPTTP53KMT2AMEN1 | |
| SCHEMBL12541097 | 0.79 | CDK4 (0.44) | PNMTMAPTTP53KMT2AMEN1 | |
| SCHEMBL31396702 | 0.79 | CD274 (0.57) | MAPTKMT2AMEN1LMNA | |
| SCHEMBL28890009 | 0.78 | MAPT (0.40) | PNMTRAD52RECQLMAPTTP53 | |
| SCHEMBL1040520 | 0.78 | CYP2C9 (0.47) | — | |
| SCHEMBL23609445 | 0.77 | ADORA2A (0.41) | PNMTRAD52RECQLMAPTGRM5 | |
| SCHEMBL18549833 | 0.77 | PDCD1 (0.42) | MAPTTP53KMT2ARAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765447-B1 | TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2023-07-12 | — | — | EP | disclosed |
| WO-2020207260-A1 | CDK INHIBITOR AND APPLICATION THEREOF | 珠海宇繁生物科技有限责任公司 | 2020-10-15 | — | — | WO | disclosed |
| WO-2016192630-A1 | COMPOUND HAVING KINASE INHIBITING ACTIVITY, METHOD OF PREPARING SAME, AND USE OF SAME | 中国科学院上海药物研究所 | 2016-12-08 | — | — | WO | disclosed |