Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 6/20 | 0.71 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | HRH2 | P25021 | 1/20 | 0.64 |
| ▸ | HTR1D | P28221 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | HTR5A | P47898 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.64 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1828982 | 1.00 | OGA (0.71) | OGAHRH4HRH3ADRA2BADRA2C | |
| SCHEMBL846741 | 0.87 | OGA (0.73) | OGAHRH4HRH3ADRA2BADRA2C | |
| SCHEMBL1588064 | 0.84 | OGA (0.72) | OGAHRH4HRH3ADRA2BADRA2C | |
| SCHEMBL26708279 | 0.81 | OGA (0.79) | OGAHRH4HRH3ADRA2BADRA2C | |
| Tp-040N SCHEMBL1587977 | 0.78 | HRH4 (1.00) | OGAHRH4HRH3ADRA2BADRA2C | |
| SCHEMBL847524 | 0.78 | HRH4 (0.73) | OGAHRH4HRH3ADRA2BADRA2C | |
| SCHEMBL1588714 | 0.77 | HRH4 (0.69) | OGAHRH4HRH3ADRA2BADRA2C | |
| SCHEMBL604034 | 0.74 | HRH4 (0.70) | OGAHRH4HRH3 | |
| SCHEMBL846870 | 0.74 | HRH4 (0.70) | OGAHRH4HRH3 | |
| SCHEMBL604033 | 0.74 | HRH4 (0.70) | OGAHRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315521-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H 4 RECEPTOR | Janssen Pharmaceutica NV (BE) | 2011-05-04 | — | — | EP | disclosed |
| WO-2009152325-A1 | DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-17 | — | — | WO | disclosed |