Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.30 |
| ▸ | CCNC | P24863 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14111368 | 0.84 | MAPT (0.35) | KDM4EALDH1A1LMNACYP3A4TSHR | |
| SCHEMBL10202937 | 0.82 | KDM4E (0.35) | KDM4EALDH1A1SMN1; SMN2LMNACYP3A4 | |
| SCHEMBL11948261 | 0.76 | GBA1 (0.38) | KDM4EALDH1A1CYP1A2RAB9A | |
| SCHEMBL12027255 | 0.75 | BACE1 (0.39) | CYP1A2CYP2C19 | |
| SCHEMBL14930076 | 0.74 | HDAC1 (0.41) | ALDH1A1CYP3A4CYP1A2MAPTCYP2C9 | |
| SCHEMBL15526283 | 0.72 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2LMNACYP3A4 | |
| SCHEMBL539420 | 0.72 | KDM4E (0.53) | KDM4EALDH1A1SMN1; SMN2LMNACYP3A4 | |
| SCHEMBL19783105 | 0.71 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2LMNACYP3A4 | |
| SCHEMBL11948259 | 0.71 | TAAR1 (0.41) | SMN1; SMN2LMNANPC1 | |
| SCHEMBL16126541 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196393-A2 | AUTOPHAGY-INHIBITING COMPOUNDS AND USES THEREOF | PRESAGE BIOSCIENCES, INC. (US) | 2016-12-08 | — | — | WO | disclosed |