Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | MTOR | P42345 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 10/20 | 0.46 |
| ▸ | DRD2 | P14416 | 8/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037567 | 0.78 | HRH3 (0.41) | PIK3CAMTORMEN1KMT2A | |
| SCHEMBL18291605 | 0.78 | PIK3CA (0.41) | PIK3CAMTOR | |
| SCHEMBL18822758 | 0.77 | HRH3 (0.54) | PIK3CAMTOR | |
| SCHEMBL29414467 | 0.77 | HRH3 (0.54) | PIK3CAMTOR | |
| SCHEMBL20255126 | 0.76 | PIK3CA (0.34) | PIK3CAMTORDRD3DRD2MEN1 | |
| SCHEMBL29414456 | 0.76 | GRM5 (0.56) | MTORMEN1KMT2A | |
| SCHEMBL107791 | 0.76 | GRM5 (0.56) | MTORMEN1KMT2A | |
| SCHEMBL18291471 | 0.75 | HTR2A (0.35) | PIK3CAMTORDRD3MEN1KMT2A | |
| SCHEMBL1990029 | 0.74 | KMT2A (0.57) | MEN1KMT2A | |
| SCHEMBL20255387 | 0.74 | GCKR (0.33) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016194831-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | 帝人ファーマ株式会社 | 2016-12-08 | — | — | WO | disclosed |