Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 17/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | PDE9A | O76083 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291855 | 0.92 | PDE2A (0.49) | PDE2APTGDR2PDE9A | |
| SCHEMBL18290682 | 0.91 | PDE2A (0.50) | PDE2A | |
| SCHEMBL18290680 | 0.91 | PDE2A (0.48) | PDE2APTGDR2 | |
| SCHEMBL18290659 | 0.90 | PDE2A (0.53) | PDE2A | |
| SCHEMBL18291814 | 0.89 | PDE2A (0.52) | PDE2A | |
| SCHEMBL18290658 | 0.88 | PDE2A (0.50) | PDE2A | |
| SCHEMBL18290678 | 0.88 | PDE2A (0.46) | PDE2A | |
| SCHEMBL18291902 | 0.86 | PDE2A (0.49) | PDE2A | |
| SCHEMBL18291819 | 0.86 | PDE2A (0.49) | PDE2A | |
| SCHEMBL18290830 | 0.86 | PDE2A (0.75) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016191935-A1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016196071-A1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | WO | disclosed |