Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 20/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18283066 | 0.88 | PDE2A (0.63) | PDE2A | |
| SCHEMBL18283311 | 0.87 | PDE2A (0.80) | PDE2A | |
| SCHEMBL18282784 | 0.87 | PDE2A (0.80) | PDE2A | |
| SCHEMBL18282946 | 0.87 | PDE2A (0.80) | PDE2A | |
| SCHEMBL20185302 | 0.84 | PDE2A (1.00) | PDE2A | |
| SCHEMBL20185301 | 0.84 | PDE2A (1.00) | PDE2A | |
| SCHEMBL18282978 | 0.83 | PDE2A (0.69) | PDE2A | |
| SCHEMBL18283185 | 0.83 | PDE2A (0.69) | PDE2A | |
| SCHEMBL18282974 | 0.83 | PDE2A (0.69) | PDE2A | |
| SCHEMBL18282706 | 0.81 | PDE2A (0.62) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016191935-A1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | WO | disclosed |