Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182825 | 0.86 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182722 | 0.86 | PIK3CD (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL183107 | 0.86 | PIK3CD (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182771 | 0.81 | PIK3CD (0.73) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182967 | 0.79 | PIK3CA (0.68) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182818 | 0.78 | PIK3CD (0.67) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182824 | 0.78 | PIK3CD (0.63) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182889 | 0.77 | PIK3CD (0.67) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182537 | 0.77 | PIK3CD (0.64) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182951 | 0.77 | PIK3CD (0.64) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | claimed |
| EP-2049502-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | Novartis AG (CH) | 2009-04-22 | — | — | EP | claimed |
| WO-2008012326-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-31 | — | — | WO | claimed |
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | disclosed |