Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18293160 | 0.94 | MAPT (0.50) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL18293092 | 0.94 | MAPT (0.50) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL18293173 | 0.91 | MAPT (0.52) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL18285767 | 0.90 | KDM4E (0.62) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL30408128 | 0.90 | MAPT (0.48) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL18293171 | 0.90 | MAPT (0.48) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL18293112 | 0.89 | MAPT (0.48) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL18293201 | 0.89 | MAPT (0.48) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL18286046 | 0.89 | MAPT (0.49) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL18293316 | 0.89 | MAPT (0.47) | MAPTKDM4EALDH1A1NPC1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016197078-A1 | COMPOUNDS FOR THE MODULATION OF MYC ACTIVITY | SYROS PHARMACEUTICALS, INC. (US) | 2016-12-08 | — | — | WO | disclosed |