Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | APEX1 | P27695 | 8/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | UHRF1 | Q96T88 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30407997 | 0.93 | KDM4E (0.61) | KDM4EMAPTALDH1A1MEN1HTT | |
| SCHEMBL18285789 | 0.93 | KDM4E (0.61) | KDM4EMAPTALDH1A1MEN1HTT | |
| SCHEMBL13832432 | 0.90 | APEX1 (0.71) | KDM4EMAPTALDH1A1MEN1HTT | |
| SCHEMBL18293235 | 0.89 | MAPT (0.48) | KDM4EMAPTALDH1A1MEN1HTT | |
| SCHEMBL13833818 | 0.88 | KDM4E (0.80) | KDM4EMAPTALDH1A1MEN1HTT | |
| SCHEMBL20254192 | 0.87 | KDM4E (0.55) | KDM4EMAPTALDH1A1MEN1HTT | |
| SCHEMBL18285909 | 0.86 | MAPT (0.67) | KDM4EMAPTALDH1A1MEN1HTT | |
| SCHEMBL20248857 | 0.86 | MAPT (0.71) | KDM4EMAPTALDH1A1MEN1HTT | |
| SCHEMBL13833859 | 0.86 | APEX1 (0.68) | KDM4EMAPTALDH1A1MEN1HTT | |
| SCHEMBL13833776 | 0.86 | MAPT (0.59) | KDM4EMAPTALDH1A1MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016197078-A1 | COMPOUNDS FOR THE MODULATION OF MYC ACTIVITY | SYROS PHARMACEUTICALS, INC. (US) | 2016-12-08 | — | — | WO | disclosed |