Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 9/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20254258 | 1.00 | MAPT (0.58) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL20239938 | 1.00 | MAPT (0.58) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL20239939 | 1.00 | MAPT (0.58) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL22449466 | 0.97 | MAPT (0.56) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL22449467 | 0.97 | MAPT (0.56) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL20240042 | 0.91 | MAPT (0.47) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL30406967 | 0.91 | MAPT (0.47) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL18293293 | 0.91 | MAPT (0.47) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL20240041 | 0.91 | MAPT (0.47) | MAPTKDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL18293233 | 0.88 | MYC (0.47) | MAPTKDM4EALDH1A1NPC1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016197078-A1 | COMPOUNDS FOR THE MODULATION OF MYC ACTIVITY | SYROS PHARMACEUTICALS, INC. (US) | 2016-12-08 | — | — | WO | disclosed |