Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.67 |
| ▸ | LCK | P06239 | 9/20 | 0.63 |
| ▸ | BTK | Q06187 | 11/20 | 0.57 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16763593 | 0.81 | JAK3 (1.00) | JAK3LCKBTKEGFR | |
| SCHEMBL16763592 | 0.81 | JAK3 (1.00) | JAK3LCKBTKEGFR | |
| SCHEMBL20539866 | 0.80 | JAK3 (0.84) | JAK3LCKBTKEGFR | |
| SCHEMBL18283511 | 0.80 | JAK3 (0.84) | JAK3LCKBTKEGFR | |
| SCHEMBL18296208 | 0.80 | LCK (0.52) | JAK3LCKBTKEGFR | |
| SCHEMBL18283401 | 0.80 | JAK3 (0.82) | JAK3LCKBTKEGFR | |
| SCHEMBL20539748 | 0.80 | JAK3 (0.82) | JAK3LCKBTKEGFR | |
| SCHEMBL23080981 | 0.78 | JAK3 (0.84) | JAK3LCKBTKEGFR | |
| SCHEMBL16763896 | 0.78 | JAK3 (1.00) | JAK3LCKBTKEGFR | |
| SCHEMBL16764241 | 0.78 | JAK3 (1.00) | JAK3LCKBTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |