Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.54 |
| ▸ | JAK3 | P52333 | 15/20 | 0.54 |
| ▸ | LCK | P06239 | 12/20 | 0.54 |
| ▸ | EGFR | P00533 | 6/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18296430 | 0.87 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL29871745 | 0.87 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL22346882 | 0.87 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL22346873 | 0.87 | BTK (0.64) | BTKJAK3LCKEGFR | |
| SCHEMBL23081040 | 0.85 | BTK (0.49) | BTKJAK3LCKEGFR | |
| SCHEMBL18296401 | 0.85 | LCK (0.65) | BTKJAK3LCKEGFR | |
| SCHEMBL18884514 | 0.85 | BTK (0.70) | BTKJAK3LCKEGFR | |
| SCHEMBL20867957 | 0.84 | JAK3 (0.71) | BTKJAK3LCKEGFR | |
| SCHEMBL22346932 | 0.83 | BTK (0.68) | BTKJAK3LCKEGFR | |
| SCHEMBL22346936 | 0.83 | BTK (0.68) | BTKJAK3LCKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |