Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.50 |
| ▸ | JAK3 | P52333 | 11/20 | 0.50 |
| ▸ | EGFR | P00533 | 7/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.44 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.44 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18283655 | 1.00 | LCK (0.50) | LCKJAK3EGFRBRD4BMPR1B | |
| SCHEMBL18283654 | 1.00 | LCK (0.50) | LCKJAK3EGFRBRD4BMPR1B | |
| SCHEMBL18283574 | 0.82 | JAK3 (0.59) | LCKJAK3EGFRBTK | |
| SCHEMBL18283443 | 0.82 | SYK (0.51) | LCKJAK3EGFREML4ALK | |
| SCHEMBL18283441 | 0.82 | SYK (0.51) | LCKJAK3EGFREML4ALK | |
| SCHEMBL18283971 | 0.81 | BTK (0.63) | LCKJAK3EGFRBTK | |
| SCHEMBL18283969 | 0.81 | BTK (0.63) | LCKJAK3EGFRBTK | |
| SCHEMBL18296366 | 0.81 | BTK (0.63) | LCKJAK3EGFRBTK | |
| SCHEMBL23080791 | 0.76 | JAK3 (0.69) | LCKJAK3EGFRBTK | |
| SCHEMBL18296256 | 0.76 | JAK3 (0.57) | LCKJAK3EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2021-03-11 | — | — | US | disclosed |
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2021-03-11 | — | — | US | disclosed |
| US-20180305348-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC | 2018-10-25 | — | — | US | disclosed |
| EP-3310776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | Pharmacyclics LLC (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | LCK 3/4885JAK3 64/4885EGFR 705/4885 |
| US-20180305348-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | LCK 3/4885JAK3 64/4885EGFR 705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.