Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.49 |
| ▸ | SYK | P43405 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.45 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | TYK2 | P29597 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18283580 | 0.99 | BTK (0.49) | BTKSYKMAPK1KCNH2MAPK3 | |
| SCHEMBL14956030 | 0.85 | CHEK1 (0.54) | BTKSYKMAPK1KCNH2MAPK3 | |
| SCHEMBL14956031 | 0.85 | CHEK1 (0.54) | BTKSYKMAPK1KCNH2MAPK3 | |
| SCHEMBL14955662 | 0.85 | SYK (0.51) | BTKSYKMAPK1KCNH2MAPK3 | |
| SCHEMBL14955659 | 0.85 | SYK (0.51) | BTKSYKMAPK1KCNH2MAPK3 | |
| SCHEMBL14955848 | 0.83 | CHEK1 (0.53) | BTKSYKMAPK1KCNH2MAPK3 | |
| SCHEMBL14955850 | 0.83 | CHEK1 (0.53) | BTKSYKMAPK1KCNH2MAPK3 | |
| SCHEMBL14955888 | 0.81 | SYK (0.52) | BTKSYKMAPK1KCNH2MAPK3 | |
| SCHEMBL14955891 | 0.81 | SYK (0.52) | BTKSYKMAPK1KCNH2MAPK3 | |
| SCHEMBL18283652 | 0.79 | EGFR (0.52) | BTKSYKJAK3LCKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2021-03-11 | — | — | US | disclosed |
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | BTK 1/4885SYK 4/4885MAPK1 626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.