Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 15/20 | 0.50 |
| ▸ | JAK3 | P52333 | 10/20 | 0.47 |
| ▸ | LCK | P06239 | 9/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18283598 | 0.81 | BTK (0.71) | BTKJAK3LCKEGFR | |
| SCHEMBL20539806 | 0.81 | BTK (0.71) | BTKJAK3LCKEGFR | |
| SCHEMBL18296208 | 0.75 | LCK (0.52) | BTKJAK3LCKEGFR | |
| SCHEMBL20540867 | 0.75 | BTK (0.71) | BTKJAK3LCKEGFR | |
| SCHEMBL18283508 | 0.75 | BTK (0.71) | BTKJAK3LCKEGFR | |
| SCHEMBL20539808 | 0.74 | JAK3 (0.57) | BTKJAK3LCKEGFR | |
| SCHEMBL18283965 | 0.74 | JAK3 (0.57) | BTKJAK3LCKEGFR | |
| SCHEMBL20540873 | 0.73 | JAK3 (0.69) | BTKJAK3LCKEGFR | |
| SCHEMBL18283938 | 0.73 | JAK3 (0.58) | BTKJAK3LCKEGFR | |
| SCHEMBL20540486 | 0.73 | JAK3 (0.58) | BTKJAK3LCKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |