Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 7/20 | 0.53 |
| ▸ | ACACA | Q13085 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827670 | 0.89 | ACACB (0.46) | ACACBACACA | |
| SCHEMBL1830111 | 0.88 | ACACB (0.54) | ACACBACACA | |
| SCHEMBL1829668 | 0.87 | ACACB (0.46) | ACACBACACA | |
| SCHEMBL1830435 | 0.87 | ACACB (0.47) | ACACBACACACYP19A1 | |
| SCHEMBL1813377 | 0.87 | ACACB (0.54) | ACACBACACA | |
| SCHEMBL1830195 | 0.85 | ACACB (0.45) | ACACBACACACYP19A1 | |
| SCHEMBL1828716 | 0.85 | HDAC3 (0.49) | ACACBACACACYP19A1 | |
| SCHEMBL1832752 | 0.85 | ACACB (0.50) | ACACBACACACYP19A1 | |
| SCHEMBL1829262 | 0.84 | CA1 (0.44) | ACACBACACACYP19A1 | |
| SCHEMBL1828229 | 0.84 | CYP19A1 (0.46) | ACACBACACACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910375-B1 | SPIROCHROMANONE DERIVATIVES AS ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS | MERCK SHARP & DOHME (US) | 2011-05-11 | — | — | EP | claimed |