Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.53 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | ROS1 | P08922 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 10/20 | 0.51 |
| ▸ | JAK3 | P52333 | 8/20 | 0.51 |
| ▸ | BTK | Q06187 | 5/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | SIK1 | P57059 | 1/20 | 0.43 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.43 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18283766 | 0.85 | JAK3 (0.61) | LCKJAK3BTKEGFR | |
| SCHEMBL18283553 | 0.85 | JAK3 (0.61) | LCKJAK3BTKEGFR | |
| SCHEMBL18283640 | 0.85 | JAK3 (0.60) | FLT3EML4ALKRETROS1 | |
| SCHEMBL23081101 | 0.83 | FLT3 (0.57) | FLT3EML4ALKRETROS1 | |
| SCHEMBL18283733 | 0.78 | JAK3 (0.64) | LCKJAK3BTKEGFR | |
| SCHEMBL18296254 | 0.77 | JAK3 (0.55) | LCKJAK3BTKEGFR | |
| SCHEMBL23080923 | 0.76 | LCK (0.61) | LCKJAK3BTKEGFR | |
| SCHEMBL23081013 | 0.76 | JAK3 (0.77) | LCKJAK3BTKEGFR | |
| SCHEMBL23080969 | 0.74 | ALK (0.59) | FLT3EML4ALKRETROS1 | |
| SCHEMBL18283724 | 0.73 | JAK3 (0.47) | LCKJAK3BTKEGFRBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |