Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 10/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 3/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
| ▸ | CPB1 | P15086 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Histidine SCHEMBL11414815 | 1.00 | GSR (0.39) | GSRCPB2ITGB3ITGA2BDPP4 | |
| Histidine SCHEMBL23831122 | 1.00 | GSR (0.39) | GSRCPB2ITGB3ITGA2BDPP4 | |
| Phenylalanine SCHEMBL8810515 | 0.94 | ALPI (0.38) | GSRITGB3ITGA2BDPP4DPP7 | |
| Histidine SCHEMBL9222981 | 0.92 | GSR (0.33) | GSRCPB2THRB | |
| Histidine SCHEMBL9222976 | 0.92 | GSR (0.33) | GSRCPB2THRB | |
| Histidine SCHEMBL17685559 | 0.91 | GSR (0.33) | GSRCPB2GHSRTHRB | |
| D-Histidine SCHEMBL11606906 | 0.91 | SLC7A5 (0.35) | — | |
| Histidine SCHEMBL2586200 | 0.91 | SLC7A5 (0.35) | — | |
| Histidine SCHEMBL27902238 | 0.91 | SLC7A5 (0.35) | — | |
| Histidine SCHEMBL2586203 | 0.91 | SLC7A5 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3103446-A2 | PHARMACEUTICAL PREPARATION FOR PREVENTING AND TREATING PROGRESSIVE MYOPIA | Zakharov, Ivan Dmitrievich (RU) | 2016-12-14 | — | — | EP | claimed |
| EP-3103446-B1 | PHARMACEUTICAL PREPARATION FOR PREVENTING AND TREATING PROGRESSIVE MYOPIA | ZAKHAROV IVAN DMITRIEVICH (RU) | 2024-02-14 | — | — | EP | disclosed |
| EP-3103446-A2 | PHARMACEUTICAL PREPARATION FOR PREVENTING AND TREATING PROGRESSIVE MYOPIA | Zakharov, Ivan Dmitrievich (RU) | 2016-12-14 | — | — | EP | disclosed |