Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.58 |
| ▸ | MTOR | P42345 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 3/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182824 | 0.82 | PIK3CD (0.63) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182771 | 0.81 | PIK3CD (0.73) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182818 | 0.80 | PIK3CD (0.67) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182667 | 0.79 | PIK3CD (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182809 | 0.79 | PIK3CD (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182967 | 0.79 | PIK3CA (0.68) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182424 | 0.78 | PIK3CD (0.60) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182873 | 0.78 | PIK3CD (0.60) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL183107 | 0.78 | PIK3CD (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL182931 | 0.77 | PIK3CD (0.59) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | claimed |