Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1832166 | 0.86 | MTOR (0.72) | MTORCYP3A4PIK3CAKCNH2RPTOR | |
| SCHEMBL1832169 | 0.86 | MTOR (0.72) | MTORCYP3A4PIK3CAKCNH2RPTOR | |
| SCHEMBL1833633 | 0.85 | MTOR (0.74) | MTORCYP3A4PIK3CAKCNH2RPTOR | |
| SCHEMBL1834496 | 0.83 | MTOR (0.51) | MTORCYP3A4PIK3CAKCNH2RPTOR | |
| SCHEMBL1832428 | 0.80 | MTOR (0.84) | MTORCYP3A4PIK3CAKCNH2RPTOR | |
| SCHEMBL1831170 | 0.80 | MTOR (0.84) | MTORCYP3A4PIK3CAKCNH2RPTOR | |
| SCHEMBL1830914 | 0.79 | MTOR (0.68) | MTORCYP3A4PIK3CAKCNH2RPTOR | |
| SCHEMBL15189931 | 0.79 | MTOR (0.76) | MTORCYP3A4PIK3CAKCNH2RPTOR | |
| SCHEMBL1833852 | 0.78 | MTOR (0.59) | MTORCYP3A4PIK3CAKCNH2RPTOR | |
| SCHEMBL1832024 | 0.78 | MTOR (0.87) | MTORCYP3A4PIK3CAKCNH2RPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318377-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |