Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.45 |
| ▸ | IKZF3 | Q9UKT9 | 18/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.45 |
| ▸ | TNF | P01375 | 3/20 | 0.42 |
| ▸ | IL1B | P01584 | 3/20 | 0.42 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25124004 | 0.79 | CRBN (0.53) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL2252005 | 0.78 | CRBN (0.75) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL30493802 | 0.78 | CRBN (0.75) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL25219152 | 0.76 | CRBN (0.66) | CRBNIKZF3DDB1 | |
| SCHEMBL22549814 | 0.74 | CRBN (0.44) | CRBNIKZF3DDB1 | |
| SCHEMBL22549815 | 0.74 | CRBN (0.44) | CRBNIKZF3DDB1 | |
| SCHEMBL22533105 | 0.74 | CRBN (0.44) | CRBNIKZF3DDB1 | |
| SCHEMBL2250459 | 0.70 | CRBN (0.73) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL22564890 | 0.69 | CRBN (0.59) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL23565388 | 0.69 | CRBN (0.59) | CRBNIKZF3DDB1TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3106460-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | Celgene Corporation (US) | 2016-12-21 | — | — | EP | disclosed |