Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 19/20 | 0.81 |
| ▸ | MAPK8 | P45983 | 15/20 | 0.81 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | STK16 | O75716 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.51 |
| ▸ | CDK11B | P21127 | 1/20 | 0.51 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPK4 | P31152 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.51 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184151 | 0.91 | MAPK9 (0.77) | MAPK9MAPK8FLT3MAPK10CIT | |
| SCHEMBL7888888 | 0.90 | MAPK9 (1.00) | MAPK9MAPK8FLT3MAPK10CIT | |
| SCHEMBL183919 | 0.90 | MAPK9 (1.00) | MAPK9MAPK8FLT3MAPK10CIT | |
| SCHEMBL183139 | 0.79 | MAPK9 (0.79) | MAPK9MAPK8FLT3MAPK10 | |
| SCHEMBL183362 | 0.78 | MAPK9 (1.00) | MAPK9MAPK8FLT3MAPK10 | |
| SCHEMBL7888007 | 0.78 | MAPK9 (1.00) | MAPK9MAPK8FLT3MAPK10 | |
| SCHEMBL182355 | 0.78 | MAPK9 (1.00) | MAPK9MAPK8FLT3MAPK10 | |
| SCHEMBL7884776 | 0.78 | MAPK9 (1.00) | MAPK9MAPK8FLT3MAPK10 | |
| SCHEMBL14834592 | 0.77 | MAPK8 (0.52) | MAPK9MAPK8FLT3MAPK10CIT | |
| SCHEMBL183742 | 0.76 | MAPK9 (0.57) | MAPK9MAPK8FLT3MAPK10CIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401274-B1 | IMIDAZO[1,2-A]PYRIDINES AS JNK MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-10-22 | — | — | EP | disclosed |
| US-8569306-B2 | JNK modulators | HOFFMANN-LA ROCHE, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| EP-2401274-A1 | IMIDAZO [1, 2 -A]PYRIDINES AS JNK MODULATORS | F. Hoffmann-La Roche AG (CH) | 2012-01-04 | — | — | EP | disclosed |
| US-20110306618-A1 | JNK Modulators | BUETTELMANN BERND (DE) | 2011-12-15 | — | — | US | disclosed |
| WO-2010097335-A1 | IMIDAZO [1, 2 -A] PYRIDINES AS JNK MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306618-A1 | JNK Modulators | MAPK3, MAPK1, MAPK4 | MAPK9 15/4885MAPK8 11/4885FLT3 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.