Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 19/20 | 0.71 |
| ▸ | EDNRB | P24530 | 17/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | TSPO | P30536 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31442652 | 0.96 | EDNRA (0.76) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL9891390 | 0.85 | EDNRA (0.77) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL12973800 | 0.84 | EDNRA (0.78) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| Aprocitentan SCHEMBL30439551 | 0.83 | EDNRA (1.00) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| Aprocitentan SCHEMBL3646065 | 0.83 | EDNRA (1.00) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL25646617 | 0.83 | EDNRB (0.86) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL9044786 | 0.79 | EDNRA (0.89) | EDNRAEDNRB | |
| SCHEMBL9046501 | 0.79 | EDNRA (0.70) | EDNRAEDNRB | |
| SCHEMBL8267995 | 0.79 | EDNRA (0.71) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL14289223 | 0.78 | EDNRA (0.67) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016203489-A1 | PROCESS FOR THE PREPARATION OF MACITENTAN AND INTERMEDIATES THEREOF | MEGAFINE PHARMA (P) LTD. (IN) | 2016-12-22 | — | — | WO | disclosed |