Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323595 | 0.86 | KDM4E (0.44) | KDM4ESMN1; SMN2ALDH1A1CA12CA1 | |
| SCHEMBL18323621 | 0.85 | TSHR (0.44) | KDM4EALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL15907128 | 0.83 | CREBBP (0.36) | KDM4ESMN1; SMN2ALDH1A1CREBBPCA12 | |
| SCHEMBL18323588 | 0.80 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1CA12CA1 | |
| SCHEMBL18323589 | 0.78 | KDM4E (0.38) | KDM4ESMN1; SMN2ALDH1A1CA12CA1 | |
| SCHEMBL18323603 | 0.77 | KDM4E (0.41) | KDM4ESMN1; SMN2ALDH1A1CA12CA1 | |
| SCHEMBL18323592 | 0.76 | KDM5A (0.39) | KDM4ESMN1; SMN2ALDH1A1CA12CA1 | |
| SCHEMBL18323644 | 0.76 | KDM4E (0.55) | KDM4ESMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL18323631 | 0.75 | KDM4E (0.40) | KDM4ESMN1; SMN2ALDH1A1CA12CA1 | |
| SCHEMBL18323607 | 0.74 | KDM4E (0.41) | KDM4ESMN1; SMN2ALDH1A1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |