Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 15/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323661 | 0.80 | POLB (0.47) | SMN1; SMN2PBRM1L3MBTL1BRD4POLB | |
| SCHEMBL18323677 | 0.80 | POLB (0.57) | BRD4POLBKDM4EMEN1KMT2A | |
| SCHEMBL18323663 | 0.77 | SMN1; SMN2 (0.42) | SMN1; SMN2PBRM1L3MBTL1BRD4POLB | |
| SCHEMBL18323632 | 0.76 | KDM4E (0.55) | SMN1; SMN2PBRM1L3MBTL1BRD4KDM4E | |
| SCHEMBL18323671 | 0.75 | SMN1; SMN2 (0.40) | SMN1; SMN2PBRM1L3MBTL1BRD4POLB | |
| SCHEMBL18323654 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2PBRM1L3MBTL1BRD4POLB | |
| SCHEMBL11918890 | 0.72 | SMN1; SMN2 (0.38) | SMN1; SMN2PBRM1L3MBTL1BRD4POLB | |
| SCHEMBL18323577 | 0.69 | KDM4E (0.36) | BRD4KDM4EMEN1KMT2A | |
| SCHEMBL12510358 | 0.68 | CHEK1 (0.60) | SMN1; SMN2PBRM1L3MBTL1BRD4POLB | |
| SCHEMBL18323608 | 0.68 | CA12 (0.40) | SMN1; SMN2L3MBTL1BRD4POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |