Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323637 | 0.85 | KDM4E (0.41) | KDM4EPOLBDNMT1PDE2AKMT2A | |
| SCHEMBL18323653 | 0.85 | PDE2A (0.36) | KDM4EPOLBDNMT1PDE2AKMT2A | |
| SCHEMBL18323644 | 0.83 | KDM4E (0.55) | KDM4EDNMT1KMT2AMAPTHTT | |
| SCHEMBL18323645 | 0.75 | POLB (0.57) | KDM4EPOLBDNMT1 | |
| SCHEMBL18323627 | 0.72 | KDM4E (0.41) | KDM4EPOLBDNMT1 | |
| SCHEMBL18323636 | 0.72 | KDM4E (0.41) | KDM4EPOLBDNMT1 | |
| SCHEMBL18323635 | 0.70 | KDM4E (0.39) | KDM4EPOLBDNMT1 | |
| SCHEMBL18323638 | 0.67 | KDM4E (0.50) | KDM4EKMT2A | |
| SCHEMBL15907096 | 0.63 | KDM4E (0.35) | KDM4EKMT2A | |
| SCHEMBL18323607 | 0.63 | KDM4E (0.41) | KDM4EPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |