Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20386505 | 0.88 | POLB (0.47) | HTTEPHX2SMN1; SMN2POLBPKM | |
| SCHEMBL2953579 | 0.87 | HTT (0.57) | HTTSMN1; SMN2POLBPKMALDH1A1 | |
| SCHEMBL21506179 | 0.84 | HTT (0.44) | HTTSMN1; SMN2DRD2DRD3POLB | |
| SCHEMBL23119052 | 0.82 | HTT (0.46) | HTTEPHX2SMN1; SMN2POLBPKM | |
| SCHEMBL15715057 | 0.82 | MAPK1 (0.57) | HTTSMN1; SMN2DRD2DRD3POLB | |
| SCHEMBL15014622 | 0.82 | MAPK1 (0.57) | HTTSMN1; SMN2DRD2DRD3POLB | |
| SCHEMBL8395012 | 0.80 | HTT (0.69) | HTTSMN1; SMN2POLBPKMALDH1A1 | |
| SCHEMBL8393830 | 0.80 | HTT (0.63) | HTTSMN1; SMN2POLBPKMALDH1A1 | |
| SCHEMBL21161446 | 0.79 | HTT (0.49) | HTTSMN1; SMN2POLBPKMALDH1A1 | |
| SCHEMBL22875094 | 0.79 | POLB (0.58) | HTTEPHX2POLBPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922840-B1 | BICYCLIC HETEROCYCLE SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2016-12-21 | — | — | EP | disclosed |