Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 9/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18324066 | 0.77 | HDAC3 (0.58) | HDAC3HDAC1HDAC6HDAC2DRD3 | |
| SCHEMBL13039740 | 0.77 | HDAC6 (0.70) | HDAC3HDAC1HDAC6HDAC2HDAC4 | |
| SCHEMBL13039732 | 0.76 | HDAC6 (0.68) | HDAC3HDAC1HDAC6HDAC2HDAC4 | |
| SCHEMBL1938432 | 0.70 | HDAC3 (1.00) | HDAC3HDAC1HDAC6HDAC2HDAC4 | |
| SCHEMBL13039738 | 0.69 | HDAC1 (0.70) | HDAC3HDAC1HDAC6HDAC2HDAC4 | |
| SCHEMBL13039739 | 0.68 | HDAC1 (0.73) | HDAC3HDAC1HDAC6HDAC2HDAC4 | |
| SCHEMBL19835907 | 0.68 | GAA (0.60) | HDAC3HDAC1HDAC6HDAC2HDAC4 | |
| SCHEMBL13039733 | 0.66 | HDAC1 (0.70) | HDAC3HDAC1HDAC6HDAC2HDAC4 | |
| SCHEMBL22811216 | 0.64 | HDAC8 (0.58) | HDAC3HDAC1HDAC6HDAC2HDAC4 | |
| SCHEMBL1520902 | 0.64 | HDAC8 (0.78) | HDAC1HDAC7HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2330894-B1 | COMPOSITIONS INCLUDING 6-AMINOHEXANOIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORP (US) | 2016-12-21 | — | — | EP | disclosed |