Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 4/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38656021 | 0.92 | ACACB (0.38) | ACACBEPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL16800261 | 0.90 | ACACB (0.40) | ACACBNR1H2EPHX2CHRM2CHRM1 | |
| SCHEMBL19792176 | 0.90 | ACACB (0.40) | ACACBNR1H2EPHX2CHRM2CHRM1 | |
| SCHEMBL30172620 | 0.87 | ACACB (0.42) | ACACBNR1H2CYP1A2EPHX2KDM1A | |
| SCHEMBL25730009 | 0.87 | ACACB (0.39) | ACACBEPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL25922603 | 0.85 | ACACB (0.38) | ACACBEPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL27225632 | 0.83 | NR1H2 (0.37) | ACACBNR1H2CYP1A2EPHX2CHRM2 | |
| SCHEMBL30749399 | 0.81 | PEPD (0.42) | NR1H2CYP1A2EPHX2HSD17B10 | |
| SCHEMBL20553992 | 0.81 | CHRM2 (0.41) | ACACBNR1H2CYP1A2EPHX2CHRM2 | |
| SCHEMBL20553993 | 0.81 | CHRM2 (0.41) | ACACBNR1H2CYP1A2EPHX2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021055756-A1 | SPIROCYCLIC ANDROGEN RECEPTOR PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-03-25 | — | — | WO | disclosed |
| WO-2016203405-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2016-12-22 | — | — | WO | disclosed |
| WO-2016203406-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2016-12-22 | — | — | WO | disclosed |