Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 2/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.57 |
| ▸ | NPC1L1 | Q9UHC9 | 11/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | LIPC | P11150 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | HPN | P05981 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16379647 | 0.95 | PAK4 (0.63) | PAK4NAMPTPAK1NPC1L1HDAC4 | |
| SCHEMBL23365761 | 0.94 | PAK4 (0.53) | PAK4NAMPTPAK1NPC1L1HDAC4 | |
| SCHEMBL16379764 | 0.93 | PAK4 (0.55) | PAK4NAMPTPAK1NPC1L1 | |
| SCHEMBL18329009 | 0.92 | PAK4 (0.54) | PAK4NAMPTPAK1NPC1L1HDAC4 | |
| SCHEMBL29999793 | 0.92 | PAK4 (0.53) | PAK4NAMPTPAK1NPC1L1HDAC4 | |
| SCHEMBL16380107 | 0.92 | PAK4 (0.54) | PAK4NAMPTPAK1NPC1L1HDAC4 | |
| SCHEMBL16380008 | 0.92 | PAK4 (0.53) | PAK4NAMPTPAK1NPC1L1HDAC4 | |
| SCHEMBL16379812 | 0.91 | PAK4 (0.55) | PAK4NAMPTPAK1NPC1L1HDAC4 | |
| SCHEMBL16379646 | 0.90 | PAK4 (0.55) | PAK4NAMPTPAK1NPC1L1HDAC4 | |
| SCHEMBL18329042 | 0.90 | PAK4 (0.55) | PAK4NAMPTPAK1NPC1L1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210403459-A1 | SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. | 2021-12-30 | — | — | US | disclosed |
| US-20160368904-A1 | SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. | 2016-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368904-A1 | SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF | BCL6, MALT1, BTK | PAK4 2007/4885NAMPT 1663/4885PAK1 3040/4885 |
| US-20210403459-A1 | SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF | BCL6, MALT1, BTK | PAK4 2260/4885NAMPT 1782/4885PAK1 3233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.