Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.82 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.82 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.79 |
| ▸ | PDE2A | O00408 | 1/20 | 0.79 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.79 |
| ▸ | PDE6D | O43924 | 1/20 | 0.79 |
| ▸ | PDE8A | O60658 | 1/20 | 0.79 |
| ▸ | PDE9A | O76083 | 1/20 | 0.79 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.79 |
| ▸ | HTR1A | P08908 | 1/20 | 0.79 |
| ▸ | PDE6A | P16499 | 1/20 | 0.79 |
| ▸ | PDE6G | P18545 | 1/20 | 0.79 |
| ▸ | PDE4A | P27815 | 1/20 | 0.79 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.79 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.79 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.79 |
| ▸ | PDE6B | P35913 | 1/20 | 0.79 |
| ▸ | PDE6C | P51160 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24051300 | 0.94 | PDE5A (0.89) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL16972499 | 0.92 | PDE5A (0.85) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL16972470 | 0.92 | PDE5A (0.85) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL16972497 | 0.91 | PDE5A (0.84) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL16972521 | 0.91 | PDE5A (0.84) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL24051299 | 0.91 | PDE5A (0.84) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL18577850 | 0.91 | PDE5A (0.84) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL16972455 | 0.91 | PDE5A (0.84) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL30848678 | 0.91 | PDE5A (0.95) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL18592598 | 0.90 | PDE5A (0.82) | PDE5APDE3BPDE3AABCC4PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0463756-B1 | Pyrazolopyrimidinone antianginal agents | PFIZER LTD (GB) | 1995-04-19 | — | — | EP | disclosed |
| US-5346901-A | Treatment of angina, hypertension, heart failure and atherosclerosis | PFIZER INC. (US) | 1994-09-13 | — | — | US | disclosed |
| US-5250534-A | Inhibitors of cyclic guanosine 3*,5*-monophosphate phosphodiesterase | PFIZER INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0463756-A1 | Pyrazolopyrimidinone antianginal agents | Pfizer Limited (GB) | 1992-01-02 | — | — | EP | disclosed |