Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.83 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.70 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1833122 | 0.92 | MTOR (0.72) | MTORRPTORMLST8CYP3A4KCNH2 | |
| SCHEMBL1831136 | 0.91 | MTOR (0.79) | MTORRPTORMLST8CYP3A4KCNH2 | |
| SCHEMBL1833684 | 0.91 | MTOR (1.00) | MTORRPTORMLST8CYP3A4KCNH2 | |
| SCHEMBL1833682 | 0.91 | MTOR (1.00) | MTORRPTORMLST8CYP3A4KCNH2 | |
| SCHEMBL1831541 | 0.89 | MTOR (0.84) | MTORRPTORMLST8CYP3A4 | |
| SCHEMBL1831538 | 0.89 | MTOR (0.84) | MTORRPTORMLST8CYP3A4 | |
| SCHEMBL1831882 | 0.89 | MTOR (0.88) | MTORRPTORMLST8CYP3A4KCNH2 | |
| SCHEMBL1831879 | 0.89 | MTOR (0.88) | MTORRPTORMLST8CYP3A4KCNH2 | |
| SCHEMBL1831681 | 0.88 | MTOR (0.71) | MTORRPTORMLST8CYP3A4KCNH2 | |
| SCHEMBL1834816 | 0.87 | MTOR (0.80) | MTORRPTORMLST8CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318377-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |