Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.45 |
| ▸ | CA2 | P00918 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16847608 | 0.88 | MAPT (0.49) | CA1CA2TDP1MAPTKDM4E | |
| SCHEMBL19017845 | 0.88 | MAPT (0.49) | CA1CA2TDP1MAPTKDM4E | |
| SCHEMBL12285414 | 0.83 | PSMB8 (0.47) | CA1CA2TDP1MAPTPAX8 | |
| SCHEMBL24997166 | 0.83 | MAPT (0.43) | CA1CA2TDP1MAPTKDM4E | |
| SCHEMBL20067639 | 0.82 | CA1 (0.64) | CA1CA2TDP1MAPTKDM4E | |
| SCHEMBL22239381 | 0.80 | TDP1 (0.46) | CA1CA2TDP1MAPTKDM4E | |
| SCHEMBL20067638 | 0.79 | SPHK1 (0.49) | CA1CA2TDP1MAPTKDM4E | |
| SCHEMBL17650866 | 0.79 | CA1 (0.50) | CA1CA2TDP1MAPTKDM4E | |
| SCHEMBL16424839 | 0.79 | CA1 (0.52) | CA1CA2TDP1MAPTKDM4E | |
| SCHEMBL27410343 | 0.77 | CA1 (0.53) | CA1CA2TDP1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016205176-A1 | ANTIBODIES AND IMMUNOCONJUGATES | GENENTECH, INC. (US) | 2016-12-22 | — | — | WO | disclosed |