Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 14/20 | 0.73 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.58 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.58 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1834996 | 0.91 | MTOR (0.65) | MTORPIK3CAHDAC3CYP3A4RPTOR | |
| SCHEMBL1834113 | 0.88 | MTOR (0.80) | MTORPIK3CACYP3A4RPTORMLST8 | |
| SCHEMBL1832966 | 0.87 | MTOR (0.77) | MTORCYP3A4RPTORMLST8 | |
| SCHEMBL1833109 | 0.85 | MTOR (1.00) | MTORCYP3A4RPTORMLST8 | |
| SCHEMBL1832840 | 0.85 | MTOR (0.77) | MTORCYP3A4RPTORMLST8 | |
| SCHEMBL1831592 | 0.85 | MTOR (0.79) | MTORCYP3A4RPTORMLST8 | |
| SCHEMBL1831726 | 0.84 | MTOR (0.73) | MTORPIK3CACYP3A4RPTORMLST8 | |
| SCHEMBL1833134 | 0.84 | MTOR (0.75) | MTORCYP3A4RPTORMLST8 | |
| SCHEMBL1830381 | 0.84 | MTOR (0.86) | MTORCYP3A4RPTORMLST8 | |
| SCHEMBL2625450 | 0.83 | MTOR (0.88) | MTORCYP3A4RPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318377-B1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH INC (US) | 2013-08-21 | — | — | EP | claimed |
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | claimed |
| EP-2318377-B1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH INC (US) | 2013-08-21 | — | — | EP | disclosed |
| EP-2318377-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |