Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 14/20 | 0.54 |
| ▸ | PIP4K2B | P78356 | 14/20 | 0.54 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.42 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.37 |
| ▸ | CDK7 | P50613 | 2/20 | 0.36 |
| ▸ | CCNH | P51946 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18340698 | 0.96 | PIP4K2A (0.57) | PIP4K2APIP4K2BPIP4K2CPIKFYVEMAPK8 | |
| SCHEMBL18340763 | 0.94 | PIP4K2A (0.57) | PIP4K2APIP4K2BPIP4K2CPIKFYVEEGFR | |
| SCHEMBL29888558 | 0.92 | PIP4K2A (0.65) | PIP4K2APIP4K2BPIP4K2CPIKFYVEEGFR | |
| SCHEMBL20093356 | 0.92 | PIP4K2A (0.65) | PIP4K2APIP4K2BPIP4K2CPIKFYVEEGFR | |
| SCHEMBL18340738 | 0.91 | PIP4K2A (0.56) | PIP4K2APIP4K2BPIP4K2CPIKFYVEEGFR | |
| SCHEMBL20093361 | 0.88 | PIP4K2A (0.68) | PIP4K2APIP4K2BPIP4K2CPIKFYVEMAPK8 | |
| SCHEMBL18340701 | 0.87 | PIP4K2A (0.47) | PIP4K2APIP4K2BPIP4K2CPIKFYVEMAPK8 | |
| SCHEMBL20093369 | 0.86 | PIP4K2A (0.67) | PIP4K2APIP4K2BPIP4K2CPIKFYVEEGFR | |
| SCHEMBL18340771 | 0.85 | MAPK8 (0.44) | PIP4K2APIP4K2BEGFRERBB2ERBB4 | |
| SCHEMBL18340750 | 0.85 | PIP4K2A (0.43) | PIP4K2APIP4K2BPIP4K2CEGFRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3313530-A1 | 4,6-PYRIMIDINYLENE DERIVATIVES AND USES THEREOF | Dana Farber Cancer Institute, Inc. (US) | 2018-05-02 | — | — | EP | disclosed |
| WO-2016210296-A1 | 4,6-PYRIMIDINYLENE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-12-29 | — | — | WO | disclosed |